Previous - 2.5 Monitoring a Reaction (TLC)


2.6 Quenching a reaction

2.6.1 General approach

Definition: “The termination of a chemical reaction by the careful addition of a quenching agent to react quickly and irreversibly with one or more of the substrates, thus preventing further reaction” David Molyneux (2011)



Step by Step:

  1. Quench at the temperature recommended, at the rate recommended.
  2. If gas is evolved during the quench, or it is otherwise exothermic, watch the reaction carefully to be sure it is under control.


Types of Reactions:

2.6.2 Strongly basic non-aqueous reactions

2.6.3 Neutral non-aqueous reactions

2.6.4 Strongly acidic non-aqueous reactions

2.6.5 Acidic or basic aqueous reactions

2.6.6 Liquid ammonia reactions

2.6.7 Conclusion


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