Research

Our research is based on trying to find new and efficient ways for the synthesis of natural products and molecules of biological significance.


To achieve these objectives our work has focused principally on two keys areas:


1)  New methods to form C-C bonds based on metal-catalyzed hydrogen atom transfer (MHAT) reactions.


Synthetically useful methodologies with no direct precedent in the literature that can provide novel disconnection approaches to complex molecular architectures.

Radical Cyclization of Alkene-Tethered Ketones Initiated by Hydrogen-Atom Transfer

Mar Saladrigas  Caroline Bosch  Gisela V. Saborit  Josep Bonjoch*, Ben Bradshaw*

Angew. Chem. Int. Ed. 2018, 57  182-186 link

Hydrogen Atom Transfer (HAT)-Triggered Iron-Catalyzed Intra- andIntermolecular Coupling of Alkenes with Hydrazones: Access to Complex Amines

Mar Saladrigas, Guillem Loren, Josep Bonjoch*, and Ben Bradshaw*

ACS Catalysis, 2018,  8, 11699-11703

2)  Development of organocatalysed tandem reactions of biologically relevant heterocycles.


Methodologies for the one-pot synthesis of important enantiopure building blocks (for example: morphans, decahydroquinolines and octahydroindoles) that can be used as readily accesible advanced intermediates for total synthesis.  


With all our work we aim to:


  • Develop protocols that are operationally simple, efficient, selective and scalable.
  • Increase time efficiency by developing more direct synthetic routes.
  • Avoid the use of toxic reagents and the generation of chemical waste.


For an example of many of the approaches combined into total synthesis see:


A gram-scale route to phlegmarine alkaloids: rapid total synthesis of (-)-cermizine B

Bradshaw, B.; Luque. C; Bonjoch. J.
Chem. Commun., 2014, 50, 7099-7102 (link)